National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2003

17. Suppressive effects of zearalenone and its derivatives on bovine neutrophil chemiluminescence

Japanese

 The effects of zearalenone (ZEN), an estrogenic mycotoxin produced by Fusarium fungi, and its derivatives alpha- and beta-zearalenols (Zel), zearalanone (ZAN), and alpha- and beta-zearalanols (Zal) were compared using bovine neutrophil chemiluminescence, a bactericidal parameter. ZEN and Zels suppressed the chemiluminescence at a concentration of 10-5 M, whereas ZAN and Zals did not. Based on the structural difference among those substances, we concluded that possession of the C1'-2' double bond in the microlide ring is essential for zearalenones to induce neutrophil suppression.
(Safety Evaluation Section, Department of Safety Research   TEL +81-29-838-7823)

References:

  • Murata et al. (2002) Vet. Hum. Toxicol. 44:83-86.
  • Murata et al. (2003) Vet. Hum. Toxicol. 45:18-20.

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