National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2012

26. CXCL8-induced mastitis during drying-off causes prolonged secretion of neutrophil elastase, inflammatory lactoferrin-derived peptides, and CXCL8 in dairy cows

Japanese

CXCL8 is a chemokine involved in the recruitment and activation of neutrophils in inflammation. A single intramammary infusion of CXCL8 can induce prolonged mastitic symptoms in dairy cows during the drying-off period. Sustained increases were observed in the CXCL8 concentration in mastitic mammary secretions, from 8 h to 28 days post infusion (PI). In addition, the neutrophil elastase activity and the concentration of inflammatory lactoferrin-derived peptides (LDP) also increased from 1 day and 3 days PI, respectively, until 28 days PI. These results suggest that intramammary infusion of CXCL8 can elicit mastitic reactions including sustained secretions of elastase, inflammatory LDP, and CXCL8. Since increases in elastase activity and in the concentration of inflammatory LDP and CXCL8 were also observed in Staphylococcus aureus dry-period mastitis, CXCL8-induced inflammatory reactions may be involved in the pathogenesis of S. aureus dry-period mastitis.
(Dairy Hygiene Research Division)

References:

Watanabe A. et al. (2012) Vet. Med. Int. 2012: Article ID 172072

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