食品研究部門

食品機能評価ユニット

小堀 真珠子 (こぼり ますこ)
Masuko KOBORI


職名

食品健康機能研究領域 食品機能評価ユニット長

専門分野

薬学博士
食品機能学、細胞生物学


研究業績


【研究論文】

  • Nakagawa T, Itoh M, Ohta K, Hayashi Y, Hayakawa M, Yamada Y, Akanabe H, Chikaishi T, Nakagawa K, Itoh Y, Muro T, Yanagida D, Nakabayashi R, Mori T, Saito K, Ohzawa K, Suzuki C, Li S, Ueda M, Wang MX, Nishida E, Islam S, Tana, Kobori M, Inuzuka T. (2016) Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients. Neuroreport. 27(9):671-6.
  • Oike H, Aoki-Yoshida A, Kimoto-Nira H, Yamagishi N, Tomita S, Sekiyama Y, Wakagi M, Sakurai M, Ippoushi K, Suzuki C, Kobori M. (2016) Dietary intake of heat-killed Lactococcus lactis H61 delays age-related hearing loss in C57BL/6J mice. Scientific Reports. 6:23556.
  • Ippoushi K, Sasanuma M, Oike H, Kobori M, Maeda-Yamamoto M. (2016) Absolute quantification of Pru av 2 in sweet cherry fruit by liquid chromatography/tandem mass spectrometry with the use of a stable isotope-labelled peptide. Food Chem. 204:129-34.
  • Kobori M, Takahashi Y, Sakurai M, Akimoto Y, Tsushida T, Oike H, Ippoushi K. (2016) Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice. Mol Nutr Food Res. 60(2):300-12. [ダウンロード]
  • Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T. Quercetin reduces eIF2α phosphorylation by GADD34 induction. Neurobiol Aging. 2015 Sep;36(9):2509-18.
  • Nishimuro H, Ohnishi H, Sato M, Ohnishi-Kameyama M, Matsunaga I, Naito S, Ippoushi K, Oike H, Nagata T, Akasaka H, Saitoh S, Shimamoto K, Kobori M. Estimated daily intake and seasonal food sources of quercetin in Japan. (2015) Nutrients. 7(4):2345-58. [ダウンロード]
  • Kobori M, Takahashi Y, Akimoto Y, Sakurai M, Matsunaga I, Nishimuro H, Ippoushi K, Oike H, Ohnishi-Kameyama M. (2015) Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice. J Func Foods 15:551-560.
  • Oike H, Sakurai M, Ippoushi K, Kobori M. (2015) Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work. Biochem Biophys Res Commun 456(3):556-561.
  • Ni Y, Nagashimada M, Zhan L, Nagata N, Kobori M, Sugiura M, Ogawa K, Kaneko S, Ota T. (2015) Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin. Endocrinology. 156(3):987-99.
  • Ippoushi K, Sasanuma M, Oike H, Kobori M, Maeda-Yamamoto M. (2015) Absolute quantification of protein NP24 in tomato fruit by liquid chromatography/tandem mass spectrometry using stable isotope-labelled tryptic peptide standard. Food Chem. 173:238-42.
  • Kobori,M, Ni, Y. Takahashi, N. Watanabe, M. Sugiura, K. Ogawa, M. Nagashimada, S. Kaneko, S. Naito, T. Ota: β-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice. PLOS ONE.,9(5):e98294 (2014).
  • Y. Nishide, M. Tadaishi, M. Kobori, Y. Tousen, M. Kato, M. Inada, C. Miyaura, Y. Ishimi:
    Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice. J Clin Biochem Nutr. 2013 53(1), 41-8 (2013).
  • K. Nohara, Y. Tateishi, T. Suzuki, K. Okamura, H. Murai, S. Takumi, F. Maekawa, N. Nishimura, M. Kobori, T. Ito: Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic. Toxicol Sci. 129(2), 293-304 (2012).
  • K. Nagai, T. Fukushima, H. Oike, M. Kobori: High glucose increases the expression of proinflammatory cytokines and secretion of TNFα and β-hexosaminidase in human mast cells. Eur. J. Pharmacol. 687(1-3), 39-45 (2012).
  • M. Kobori, S. Masumoto, Y.Akimoto, H.Oike: Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice. Food Chem. Toxicol. 50(7):2547-53 (2012).
  • K. Ohta, A. Mizuno, S. Li, M. Itoh, M. Ueda, E. Ohta, Y. Hida, MX Wang, M. Furoi, Y. Tsuzuki, M. Sobajima, Y. Bohmoto, T. Fukushima, M. Kobori, T. Inuzuka, T. Nakagawa: Endoplasmic reticulum stress enhances γ-secretase activity. Biochem. Biophys. Res. Commun. 416(3-4), 362-366 (2011).
  • H. Oike, K. Nagai, T. Fukushima, N. Ishida, M. Kobori: Feeding Cues and Injected Nutrients Induce Acute Expression of Multiple Clock Genes in the Mouse Liver. PLoS ONE. 6(8): e23709. Aug 25 (2011).
  • H. Oike, M. Kobori, T. Suzuki, N. Ishida: Caffeine lengthens circadian rhythms in mice. Biochem Biophys Res Commun. 410(3), 654-658 (2011).
  • M. Kobori, S. Masumoto, Y. Akimoto, H. Oike: Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol. Nutr. Food Res. 55(4), 530-540 (2011).
  • H. Oike, K. Nagai, T. Fukushima, N. Ishida, M. Kobori: High-salt diet advances molecular circadian rhythms in mouse peripheral tissues. Biochem Biophys Res Commun. 402(1), 7-13 (2011).
  • K. Ohta, A. Mizuno, M. Ueda, S. Li, Y. Suzuki, Y. Hida, Y. Hayakawa-Yano, M. Itoh, E. Ohta, M. Kobori, T. Nakagawa, Autophagy impairment stimulates PS1 expression and gamma-secretase activity. Autophagy. 345-352 (2010).
  • M. Kobori, S. Masumoto, Y. Akimoto, Y. Takahashi: Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Mol. Nutr. Food Res. 53(7), 859-868 (2009).
  • K. Nagai, Y. Takahashi, I. Mikami, T. Fukusima, H. Oike, M. Kobori: Fisetin suppresses mast cell activation induced by interaction with activated T cell membranes. Br. J. Pharmacol. 158(3), 907-919 (2009).
  • K. Fukushima, K. Nagai, Y. Hoshi, S. Masumoto, I. Mikami, Y. Takahashi, H. Oike, M. Kobori: Drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells. J Ethnopharmacol. 125(1), 90-96 (2009).
  • S. Masumoto, Y. Akimoto, H. Oike, M. Kobori: Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice. J Agric. Food Chem. 57(11), 4651-4656 (2009).
  • M. Niwa, K. Nagai, H. Oike, M. Kobori: Evaluation of the skin irritation using a DNA microarray on a reconstructed human epidermal model. Biol. Pharm. Bull. 32(2), 203-208 (2009).
  • H. Oike, M. Kobori: Resveratrol Regulates Circadian Clock Genes in Rat-1 Fibroblast Cells. Biosci Biotech Biochem.72(11):3038-3040 (2008).
  • M. Kobori, M. Ohnishi-Kameyama, Y. Akimoto, C. Yukizaki, M. Yoshida: α-eleostearic acid and its dihydroxy derivative are major apoptosis inducing components of bitter gourd. J Agric. Food Chem. 56(22), 10515-10520 (2008).
  • M. Kobori, H. Nakayama, K. Fukushima, M. Ohnishi-Kameyama, H. Ono, T. Fukushima, Y. Akimoto, S. Masumoto, C. Yukizaki, Y. Hoshi, T. Deguchi, M. Yoshida: Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses. J. Agric. Food Chem. 56(11), 4004-4011 (2008).
  • S. Fukumitsu, K. Aida, N. Ueno, S. Ozawa, Y. Takahashi, M. Kobori: Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br. J. Nutr. 100(3), 669-676 (2008).

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