食品総合研究所

先端加工技術ユニット

小林 功 (こばやし いさお)
Isao KOBAYASHI

Dr.I.Kobayashi
メールアドレス : isaok (後ろに@affrc.go.jpを追加してください)

職名

食品工学研究領域 先端加工技術ユニット

略歴

群馬県出身
1998年 東京理科大学 工学部第一部工業化学科卒業
2000年 東京理科大学大学院 工学研究科修士課程工業化学専攻修了
2003年 筑波大学大学院 農学研究科博士課程農林工学専攻修了 学位取得:博士(農学)
2003年 日本学術振興会特別研究員(PD)
(筑波大学大学院 生命環境科学研究科生物機能科学専攻)
2005年 (独)食品総合研究所 企画調整部 研究員
2006年 (独)農研機構食品総合研究所 食品工学研究領域 研究員
2008年 (独)農研機構食品総合研究所 食品工学研究領域 主任研究員(現在に至る)
2010年 農研機構長期在外研究員(Department of Biological and Agricultural Engineering, University of California, Davis, U.S.A.)

専門分野

食品プロセス工学(乳化・微粒化プロセス、消化プロセス)

研究課題

マイクロ・ナノチャネル乳化技術とその応用技術の開発
工学的手法を用いた食品の胃腸消化プロセスの解析
食品ナノ分散系の製造およびin vitro胃腸消化

主な所属学会

日本食品工学会
日本食品科学工学会
化学工学会
日本農芸化学会
化学とマイクロ・ナノシステム研究会
食品微細科学研究会

 

研究業績

【原著論文】(60件)

  • M. A. Neves, I. Kobayashi, and M. Nakajima, “Nanotechnology for bioactives delivery systems”, J. Food Drug Anal., accepted.
  • Z. Wang, L.-J. Yin, M. A. Neves, I. Kobayashi, K. Uemura, and M. Nakajima, “In vitro gastrointestinal digestability of soybean oil-in-water emulsion droplets stabilized by polyglycerol eaters of fatty acid”, Food Sci. Technol. Res., 18, 149-156 (2012).
  • I. Kobayashi, G. T. Vladisavljević, K. Uemura, and M. Nakajima, “CFD analysis of microchannel emulsification: droplet generation process and size effect of asymmetric straight-through microchannels”, Chem. Eng. Sci., 66, 5556-5565 (2011).
  • T. Kojima, N. Nagao, D. Ando, T. Ojima, Y. Kawarasaki, I. Kobayashi, M. Nakajima, and H. Nakano, “Emulsion cultivation: a miniaturized library screening system based on micro-droplet in an emulsified medium”, J. Biosci. Bioeng., 112, 299-303 (2011).
  • S. Manjula, Isao Kobayashi, and R. Subramanian, “Characterization of phospholipid reverse micelles in nonaqueous systems in relation to their rejection during membrane processing”, Food Res. Int., 44, 925-930 (2011).
  • G. T. Vladisavljević, I. Kobayashi, K. Uemura, and M. Nakajima, “Effect of dispersed phase viscosity on maximum drop generation frequency in microchannel emulsification using asymmetric straight-through channels”, Microfluid. Nanofluid., 10, 1199-1209 (2011).
  • K. Butron Fujiu, I. Kobayashi, M. Neves, K. Uemura, and M. Nakajima, “Effect of temperature on production of soybean oil-in-water emulsions by microchannel emulsification using different emulsifiers”, Food Sci. Technol. Res., 17, 77-86 (2011).
  • K. Butron Fujiu, I. Kobayashi, K. Uemura, and M. Nakajima, “Temperature effect on microchannel oil-in-water emulsification”, Microfluid. Nanofluid., 10, 773-783 (2011).
  • H. Kozu, I. Kobayashi, M. Nakajima, K. Uemura, S. Sato, and S. Ichikawa, “Analysis of flow phenomena in gastric contents induced by human gastric peristalsis using CFD”, Food Biophysics, 5, 330-336 (2010).
  • I. Kobayashi, Yoshihiro Wada, Kunihiko Uemura, and Mitsutoshi Nakajima, “Microchannel emulsification for mass production of uniform fine droplets: integration of microchannel arrays on a chip”, Microfluid. Nanofluid., 8, 255-262 (2010).
  • I. Kobayashi, Yoshihiro Wada, Kunihiko Uemura, and Mitsutoshi Nakajima, “Production characteristics of large soybean oil droplets by microchannel emulsification using asymmetric through-holes”, Japan J. Food Eng., 11, 34-48 (2010).
  • K. van Dijke, I. Kobayashi, K. Schroen, K. Uemura, M. Nakajima, and R. Boom, “Effect of viscosities of dispersed and continuous phases in microchannel oil-in-water emulsification”, Microfluid. Nanofluid., 9, 77-85 (2010).
  • K. Uemura, C. Takahashi, and I. Kobayashi, “Inactivation of Bacillus subtilis spores in soybean milk by radio-frequency flash heating”, J. Food. Eng., 100, 622-626 (2010).
  • K. Uemura, I. Kobayashi, and T. Inoue, “Inactivation of Bacillus Subtilis spores in orange juice and the quality change by high electric field alternating current”, Japan Agri. Res. Quarterly, 44, 61-66 (2010).
  • I. Kobayashi, M. A. Neves, T. Yokota, K. Uemura, and M. Nakajima, “Generation of geometrically confined droplets using microchannel arrays: effects of channel and step structure”, Ind. Eng. Chem. Res., 48, 8848-8855 (2009).
  • I. Kobayashi, Y. Murayama, T. Kuroiwa, K. Uemura, and M. Nakajima, “Production of monodisperse water-in-oil emulsions consisting of highly uniform droplets using asymmetric straight-through microchannel arrays”, Microfluid. Nanofluid., 7, 107-119 (2009).
  • I. Kobayashi, Kunihiko Uemura, and Mitsutoshi Nakajima, “Effect of channel and operation parameters on emulsion production using oblong straight-through microchannel arrays”, Japan J. Food Eng., 10, 69-75 (2009).
  • A. M. Chuah, T. Kuroiwa, I. Kobayashi, X. Zhang, and M. Nakajima, “Preparation of uniformly sized alginate microspheres using the novel combined methods of microchannel emulsification and external gelation”, Colloids Surf. A: Physicochem. Eng. Aspects, 351, 9-17 (2009).
  • T. Kuroiwa, H. Kiuchi, K. Noda, I. Kobayashi, M. Nakajima, K. Uemura, S. Sato, S. Mukataka, and S. Ichikawa, “Controlled preparation of giant vesicles employing microchannel emulsification with bilayer-forming lipids as emulsifiers”, Microfluid. Nanofluid., 6, 811-821 (2009).
  • A. M. Chuah, T. Kuroiwa, I. Kobayashi, and M. Nakajima“Effect of chitosan on the stability and properties of modified lecithin stabilized oil-in-water monodisperse emulsions prepared by microchannel emulsification”, Food Hydrocolloids, 23, 600-610 (2009).
  • M. A. Neves, Isao Kobayashi, and Mitsutoshi Nakajima, “Development of microchannel emulsification technology for monodisperse soybean and olive oil-in-water emulsions”, J. Arid Lad Studies, 19, 97-100 (2009).
  • L.-J. Yin, B.-S. Chu, I. Kobayashi, and M. Nakajima, “Performance of selected emulsifiers and their combination in the preparation of β-carotene nanodispersions”, Food Hydrocolloids, 23, 1617-1622 (2009).
  • A. M. Chuah, T. Kuroiwa, S. Ichikawa, I. Kobayashi, and M. Nakajima, “Formation of self-assembled nanoparticles by chitosan and modified-lecithin”, J. Food Sci., 74, N1-N8 (2009).
  • K. Uemura, I. Kobayashi, and T. Inoue, “Inactivation of Alicyclobacillus acidoterrestris in orange juice by high electric field alternating current”, Food. Sci. Technol. Res., 15, 211-216 (2009).
  • I. Kobayashi, Y. Wada, K. Uemura, and M. Nakajima, “Drop generation via symmetric and asymmetric through-hole arrays micromachined in stainless steel plates”, Microfluid. Nanofluid., 5, 677-687 (2008).
  • I. Kobayashi, T. Takano, R. Maeda, Y. Wada, K. Uemura, and M. Nakajima, “Straight-through microchannel devices for generating monodisperse emulsion droplets several microns in size”, Microfluid. Nanofluid., 4, 167-177 (2008).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “Generation characteristics of highly uniform nonspherical droplets of soybean oil using microchannel array devices”, Food Biophysics, 3, 132-139 (2008).
  • I. Kobayashi, S. Hirose, T. Kato, Y. Zhang, K. Uemura, and M. Nakajima, “High-aspect-ratio through-hole array microfabricated on a PMMA plate for monodisperse emulsion production”, Microsyst. Technol., 14, 1349-1357 (2008).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “Breakup of monodisperse oil-in-water emulsion droplets in microchannel array devices at low applied pressures”, J. Chem. Eng. Japan, 41, 420-426 (2008).
  • M.A. Neves, H.S. Ribeiro, I. Kobayashi, and M. Nakajima, “Encapsulation of lipophilic bioactive components by microchannel emulsification”, Food Biophysics, 3, 126-131 (2008).
  • M.A. Neves, H.S. Ribeiro, I. Kobayashi, and M. Nakajima, “Generation characteristics of highly uniform nonspherical droplets of soybean oil using microchannel array devices”, Food Biophysics, 3, 126-131 (2008).
  • G.T. Vladisavljević, I. Kobayashi, and M. Nakajima, “Generation of highly uniform droplets asymmetric microchannels fabricated on a single crystal silicon plate: effect of emulsifiers and oil types”, Powder Technol., 183, 37-48 (2008).
  • L.-J. Yin, I. Kobayashi, and M. Nakajima, “Effect of polyglycerol esters of fatty acids on physicochemical properties and stability of β-carotene emulsions during digesting in simulated gastric fluid”, Food Biophysics, 3, 213-218 (2008).
  • Y. Shinohara, T. Takizawa, S. Ueno, K. Sato, I. Kobayashi, M. Nakajima, and Y. Amemiya, “Microbeam X-ray diffraction analysis of interfacial heterogeneous nucleation of n-hexadecane inside oil-in-water emulsion droplets”, Crystal Growth & Design, 8, 3123-3126 (2008).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “CFD analysis of generation of soybean oil-in-water emulsion droplets using rectangular straight-through microchannels”, Food Sci. Technol. Res., 13, 187-192 (2007). (Best Paper Award)
  • I. Kobayashi, K. Uemura, and M. Nakajima, “Formulation of monodisperse emulsions using submicron-channel arrays”, Colloid Surf. A, 296, 285-289 (2007).
  • G.T. Vladisavljević, I. Kobayashi, M. Nakajima, R.A. Williams, M. Shimizu, and T. Nakashima, “Shirasu Porous Glass membrane emulsification: Characterization of membrane structure by high-resolution X-ray microtomography and microscopic observation of droplet formation in real time”, J. Membr. Sci., 302, 243-253 (2007).
  • 植村邦彦,小林 功,井上孝司,中嶋光敏, “交流高電界処理における電極内部の温度分布の解析”, 食総研報, 71, 27-32 (2007).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “Controlled generation of monodisperse discoid droplets using microchannel arrays”, Langmuir, 22, 10893-10897 (2006).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “CFD study of the effect of a fluid flow in a channel on generation of oil-in-water emulsion droplets in straight-through microchannel emulsification”, J. Chem. Eng. Japan, 39, 855-863 (2006).
  • M. Saito, L.-J. Yin, I. Kobayashi, and M. Nakajima, “Comparison of stability of bovine serum albumin-stabilized emulsions prepared by microchannel emulsification and homogenization”, Food Hydrocolloids, 20, 1020-1028 (2006).
  • I. Kobayashi, S. Mukataka, and M. Nakajima, “Novel asymmetric through-hole array microfabricated on a silicon plate for formulating monodisperse emulsions”, Langmuir, 21, 7629-7632 (2005).
  • I. Kobayashi, S. Mukataka, and M. Nakajima, “Production of monodisperse oil-in-water emulsions using a large silicon straight-through microchannel plate”, Ind. Eng. Chem. Res., 44, 5852-5856 (2005).
  • I. Kobayashi, S. Mukataka, and M. Nakajima, “Effects of type and physical properties of oil phase on oil-in-water emulsion droplet formation in straight-through microchannel emulsification, Experimental and CFD studies”, Langmuir, 21, 5722-5730 (2005).
  • Y. Shinohara, N. Kawasaki, S. Ueno, I. Kobayashi, M. Nakajima, and Y. Amemiya, “Observation of the transient rotator phase of n-hexadecane in emulsified droplets with time-resolved two-dimensional small- and wide-angle X-ray scattering”, Phys. Rev. Lett., 94, 097801 (2005).
  • I. Kobayashi, X. Lou, S. Mukataka and M. Nakajima, “Preparation of monodisperse W/O/W emulsions using microfluidization and straight-through microchannel emulsification”, J. Am. Oil Chem. Soc., 82, 65-71 (2005).
  • M. Saito, L.-J. Yin, I. Kobayashi, and M. Nakajima, “Preparation characteristics of monodispersed oil-in-water emulsions with large particles stabilized by proteins in straight-through microchannel emulsification”, Food Hydrocolloids, 19, 745-751 (2005).
  • I. Kobayashi, S. Mukataka, and M. Nakajima, “CFD simulation and analysis of emulsion droplet formation from straight-through microchannels”, Langmuir, 20, 9868-9877 (2004).
  • I. Kobayashi, S. Mukataka, and M. Nakajima, “Effect of slot aspect ratio on droplet formation from silicon straight-through microchannels”, J. Colloid Interface Sci., 279, 277-280 (2004).
  • I. Kobayashi, M. Nakajima, and S. Mukataka, “Preparation characteristics of oil-in-water emulsions using differently charged surfactants in straight-through microchannel emulsification”, Colloids Surfaces A, 229, 33-41 (2003).
  • I. Kobayashi, Y. Iitaka, S. Iwamoto, S. Kimura, and M. Nakajima, “Preparation characteristics of lipid microspheres using microchannel emulsification and solvent evaporation methods”, J. Chem. Eng. Japan, 36, 996-1000 (2003).
  • 岩本悟志,早田伸洋,小林 功,菊池祐二,中嶋光敏:精密ろ過膜を用いた微粒子分級挙動の可視化, 食総研報, 66, 29-32 (2002).
  • Y. Hamada, I. Kobayashi, M. Nakajima, and K. Sato, “Optical and interfacial tension study of crystallization of n-alkane in oil-in-water emulsion using monodispersed droplets”, Cryst. Growth Des., 2, 579-584 (2002).
  • M. Yasuno, M. Nakajima, S. Iwamoto, T. Maruyama, S. Sugiura, I. Kobayashi, A. Shono, and K. Satoh, “Visualization and characterization of SPG membrane emulsification”, J. Membr. Sci., 210, 29-37 (2002).
  • I. Kobayashi and M. Nakajima, “Effect of emulsifiers on the preparation of food-grade oil-in-water emulsions using a straight-through extrusion filter”, Eur. J. Lipid Sci. Technol., 104, 720-727 (2002).
  • I. Kobayashi, M. Yasuno, S. Iwamoto, A. Shono, K. Satoh, and M. Nakajima, “Microscopic observation of emulsion droplet formation from a polycarbonate membrane”, Colloids Surfaces A, 207, 185-196 (2002).
  • I. Kobayashi, M. Nakajima, K. Chun, Y. Kikuchi, and H. Fujita, “Silicon array of elongated through-holes for monodisperse emulsion droplets”, AIChE J., 48, 1639-1644 (2002).
  • M. Nakajima, S. Sugiura, I. Kobayashi, and Y. Kikuchi, “Novel microchannel emulsification for monodisperse microspheres”, Hemorheology Related Res., 4, 53-57 (2001).
  • I. Kobayashi, M. Nakajima, H. Nabetani, Y. Kikuchi, A. Shohno, and K. Satoh, “Preparation of micron-scale monodisperse oil-in-water microspheres by microchannel emulsification”, J. Am. Oil Chem. Soc., 78, 797-802 (2001).
  • I. Kobayashi, M. Nakajima, J. Tong, T. Kawakatsu, H. Nabetani, Y. Kikuchi, A. Shohno, and K. Satoh, “Production and characterization of monodispersed oil-in-water microspheres using microchannels”, Food Sci. Technol. Res., 5, 350-355 (1999).

【総説】

  • G. T. Vladisavljević, I. Kobayashi, and M. Nakajima, “Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices”, Microfluid. Nanofluid., doi:10.1007/s10404-012-0948-0
  • S. Neethirajan, I. Kobayashi, M. Nakajima, D. Wu, S. Nandagopal, F. Lin, “Microfluidics for food, agriculture and biosystems industries”, Lab Chip, 11, 1574-1586 (2011).
  • 小林 功, 植村邦彦, “マイクロチャネル乳化による単分散エマルション製造技術”, 食糧, 47, 21-34 (2009).
  • 小林 功, 中嶋光敏, “マイクロチャネル乳化技術:単分散エマルションの作製と応用”, 日本食品科学工学会誌, 53, 317-326 (2006).

【著書(分担執筆)】

  • I. Kobayashi, S. Ichikawa, M.A. Neves, T. Kuroiwa, and M. Nakajima, “Formulation of lipid micro/nanodispersion systems”, Lipids in Nanotechnology, M. Ahmad (Ed.), 95-133 (2011).
  • 小林 功, 神津博幸, 市川創作, “消化管内流動現象のシミュレーション”, 進化するテクスチャー研究, エヌ・ティー・エス,95-100 (2011).
  • H. S. Ribeiro, J. Janssen, I. Kobayashi, and M. Nakajima, “Membrane emulsification for food applications”, Membrane Technology Vol. 3. Membranes for Food Applications, K.-V. Peinemann, S. P. Nunes, and L. Giorno (Eds.), 149-171 (2010).
  • 小林 功, 中嶋光敏, “ナノ精度加工技術とマイクロチャネル乳化システム”, フードナノテクノロジー, シー・エム・シー出版, 126-132 (2009).
  • M. A. Neves, 小林 功, 中嶋光敏, “抗酸化ナノ食品素材の製造”, シー・エム・シー出版, 95-103 (2009).
  • 小林 功, 中嶋光敏, “ナノ精度加工技術とマイクロチャネル乳化システム”, 各種乳化技術ノウハウ・事例集, 情報機構, 852-863 (2009).
  • I. Kobayashi, K. Uemura, and M. Nakajima, “Recent developments in producing monodisperse emulsions using straight-through microchannel array devices”, Topics in Colloid and Interface Science Vol. 1., T. F. Tadros (Ed.), 133-156 (2009).
  • 小林 功, 中嶋光敏, “マイクロチャネルアレイを用いた均一サイズ非球形微小液滴の作製と形状制御”, 有機分散系の分散・凝集技術 第II編第7章, シー・エム・シー出版 (2008).
  • I. Kobayashi and M. Nakajima, “Generation and Multiphase Flow of Emulsions in Microchannels”, Advanced Micro and Nanosystems Vol. 5. Micro Process Engineering, N. Kockmann (Ed.), 149-171 (2006). (Part of Book Cover)
  • 和田芳弘, 小林 功, 中嶋光敏, “マイクロチャネル型量産用乳化装置の開発”, マイクロリアクターテクノロジー ~限りない可能性と課題~,エヌ・ティー・エス,299-308 (2005).
  • 小林 功, 中嶋光敏, “単分散エマルション生成のためのマイクロチャネル技術”, 微粒子工学大全 第I巻基本技術, フジテクノシステム, 735-740 (2001).

【特許(国内)】

  • 中嶋光敏, 小林 功, 植村邦彦, “マイクロスフィアの製造装置および製造方法”, 特開2007-229543
  • 中嶋光敏, 小林 功, “マイクロスフィアの製造装置および製造方法”, 特許第3772182号
  • 中嶋光敏, 藤田博之, 菊池佑二, 小林 功, “マイクロスフィアの製造方法および製造装置”, 特許第3511238号
  • 中嶋光敏, 菊池佑二, 佐野 洋, 鍋谷浩志, 川勝孝博, 小林 功, 鷹尾宏之進, “マイクロスフィアの連続製造装置”, 特許第3081880号

【共同研究実績(大学・研究機関)】

  • 筑波大学
  • 東京大学
  • 工学院大学
  • 東京都市大学
  • 名古屋大学
  • 広島大学
  • (独)産業技術総合研究所
  • Loughborough University(英国)
  • Wageningen University(オランダ)
  • Lund University(スウェーデン)
  • University of California, Davis(米国)

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